Levothyroxine sodium tablets were manufactured by a direct compression process comprising the following steps:

   * preparation of a levothyroxine sodium triturate with a portion of the microcrystalline cellulose by simple blending
   * blending the remainder of the microcrystalline cellulose and pregelatinised starch with the levothyroxine sodium triturate to produce a uniform content of active substance;
   * addition of the talc, silicon dioxide colloidal and magnesium stearate, followed by blending to prepare a powder mixture;
   * compression of levothyroxine sodium tablets at a crushing strength of not less than 30N (3Kp) and a resulting strength of 35-100N (3.5-10Kp).