to manage or influence skillfully, esp. in an unfair manner

to manipulate people's feelings.

to handle, manage, or use, esp. with skill, in some process of treatment or performance

to manipulate a large tractor.

to adapt or change (accounts, figures, etc.) to suit one's purpose or advantage.

Medicine/Medical . to examine or treat by skillful use of the hands, as in palpation, reduction of dislocations, or changing the position of a fetus.