not fit; not adapted or suited; unsuitable

He was unfit for his office.

unqualified or incompetent.

not physically fit or in due condition.

Biology . pertaining to an organism or population that is not adapted to prevailing conditions or is not producing offspring in sufficient numbers to maintain its contribution to the gene pool of the next generation.

to render unfit or unsuitable; disqualify.

noun

improperness , inappropriateness , unbecomingness , unseemliness , unsuitability , unsuitableness