to cause (a train, streetcar, etc.) to run off the rails of a track.

to cause to fail or become deflected from a purpose; reduce or delay the chances for success or development of

Being drafted into the army derailed his career for two years.

(of a train, streetcar, etc.) to run off the rails of a track.

to become derailed; go astray.

a track device for derailing rolling stock in an emergency.

verb

thwart , deflect , crash , hinder , wreck