to turn away in feeling or affection; make unfriendly or hostile; alienate the affections of

Their quarrel estranged the two friends.

to remove to or keep at a distance

The necessity for traveling on business has estranged him from his family.

to divert from the original use or possessor.

noun

connection , marriage , union

noun

alienation , antagonization , breach , break-up , disaffection , disassociation , disunity , division , divorce , hostility , leave , leaving , parting , removal , schism , separation , split , withdrawal , withholding , break , fissure , rent , rift , rupture