to accustom to hardship, difficulty, pain, etc.; toughen or harden; habituate (usually fol. by to )

inured to cold.

to come into use; take or have effect.

to become beneficial or advantageous.

verb

acclimate , familiarize , habituate , harden , make ready , season , toughen , train , condition , wont , acclimatize , accustom , adapt , desensitize , discipline , teach , use