to reduce or exhaust the strength of, as by exertion; make weary; fatigue

The long walk tired him.

to exhaust the interest, patience, etc., of; make weary; bore

Your stories tire me.

to have the strength reduced or exhausted, as by labor or exertion; become fatigued; be sleepy.

to have one's appreciation, interest, patience, etc., exhausted; become or be weary; become bored (usually fol. by of )

He soon tired of playing billiards.

British Dialect . fatigue.

adjective

draining , exhausting , fatiguing , wearing , wearying , demanding , exacting , taxing