an act or instance of exasperating; provocation.

the state of being exasperated; irritation; extreme annoyance

Her exasperation at being interrupted was understandable.

noun

calming , calmness , comfort , ease , placation , pleasing , soothing

noun

aggravation , anger , annoyance , besetment , bother , botheration , displeasure , exacerbation , fury , ire , irritant , irritation , nuisance , passion , pest , pique , plague , rage , resentment , vexation , wrath , bothering , harassment , pestering , provocation