a person or thing that ruins or spoils

Gambling was the bane of his existence.

a deadly poison (often used in combination, as in the names of poisonous plants)

wolfsbane; henbane.

death; destruction; ruin.

Obsolete . that which causes death or destroys life

entrapped and drowned beneath the watery bane.

noun

advantage , blessing , fortune , good luck

noun

affliction , bte noir , blight , burden , calamity , curse , despair , destruction , disaster , downfall , fatal attraction , misery , nuisance , pest , plague , poison , ruin , ruination , scourge , torment , trial , trouble , undoing , venom , woe , devastation , havoc , wrack , wreck , wreckage , canker , contagion , toxin , virus , destroyer , wrecker , evil , ill , death , harm , injury , mischief , murder , nemesis