grievous distress, affliction, or trouble

His woe was almost beyond description.

an affliction

She suffered a fall, among her other woes.

an exclamation of grief, distress, or lamentation.

noun

happiness , joy

noun

adversity , affliction , agony , anguish , bemoaning , blues * , burden , calamity , care , cataclysm , catastrophe , curse , dejection , deploring , depression , disaster , distress , dole , drag , gloom , grief , grieving , hardship , headache * , heartache * , heartbreak , lamentation , melancholy , misadventure , misery , misfortune , pain , rain * , regret , rue , sadness , sorrow , tragedy , trial , tribulation , trouble , unhappiness , wretchedness , hurt , torment , torture , wound , suffering , bane , evil , ill , plague , scourge , despair , dismay , dolor , heartache