a state of pain, distress, or grief; misery

They sympathized with us in our affliction.

a cause of mental or bodily pain, as sickness, loss, calamity, or persecution.

noun

aid , comfort , consolation , health , help , relief

noun

adversity , anguish , calamity , cross , crux , depression , difficulty , disease , disorder , distress , grief , hardship , illness , infirmity , misery , misfortune , ordeal , pain , plague , plight , scourge , sickness , sorrow , suffering , torment , trial , tribulation , trouble , woe , agony , hurt , torture , wound , wretchedness , indisposition , bane , evil , ill , abuse , ailment , annoyance , bereavement , botheration , buffeting , curse , epidemic , handicap , incapacitation , infestation , infliction , injury , malady , nuisance , vexation , visitation , worry