not easy in body or mind; uncomfortable; restless; disturbed; perturbed.

not easy in manner; constrained; awkward.

not conducive to ease; causing bodily discomfort.

noun

angst , anxiousness , care , concern , disquiet , disquietude , distress , nervousness , solicitude , unease , worry , inquietude , restiveness , unrest , agitation , alarm , anxiety , apprehension , compunction , constraint , disbelief , discomfort , discontent , displeasure , doubt , dread , dyspathy , dysphoria , embarrassment , fear , instability , malaise , misgiving , penitence , perturbation , qualm , queasiness , remorse , restlessness , scruple , trouble , uncertainty

adjective

dysphoric , erethic , restless , uneasy