keen mental suffering or distress over affliction or loss; sharp sorrow; painful regret.

a cause or occasion of keen distress or sorrow. ?

come to grief, to suffer disappointment, misfortune

or other trouble; fail

Their marriage came to grief after only two years.

good grief, (used as an exclamation of dismay, surprise

or relief)

Good grief, it's started to rain again!

noun

delight , ecstasy , exhilaration , happiness

noun

affliction , agony , anguish , bemoaning , bereavement , bewailing , care , dejection , deploring , depression , desolation , despair , despondency , discomfort , disquiet , distress , dole , dolor , gloom , grievance , harassment , heartache , heartbreak , infelicity , lamentation , lamenting , malaise , melancholy , misery , mortification , mournfulness , mourning , pain , purgatory , regret , remorse , repining , rue , sadness , sorrow , torture , trial , tribulation , trouble , unhappiness , vexation , woe , worry , wretchedness , adversity , annoyance , chagrin , emotion , frustration , hardship , harm , hurt , misadventure , misfortune , suffering , tears